The Pandemic of Corruption and More Bioshock News
Eric Renderking Fisk | June 29th, 2020
Jason Cousineau and Eric Rederking Fisk start the show talking about the shocking news about the article "A GENE-EDITING EXPERIMENT ON HUMAN EMBRYOS WENT HORRIBLY WRONG" that was published on 'The Futurist' website and talk about the implied danger of playing with "CRISPR" on everything to virus's to human beings.
Then Jason and Eric talk about the controversial book; "Plague of Corruption: Restoring Faith in the Promise of Science" by Dr. Judy Mikovits and Dr. Kent Heckenlively, specifically about how tainted immunizations with carry-on virus's and animal or human fetus material may be the leading cause of outbreaks of modern diseases and chronic medical conditions.
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Show Notes and Links
Amazon: “Plague of Corruption: Restoring Faith in the Promise of Science,” by Judy Mikovits and Kent Heckenlively with a Forwared by Robert F. Kennedy Jr.
Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys’ club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried.
From her doctoral thesis, which changed the treatment of HIV-AIDS, saving the lives of millions, including basketball great Magic Johnson, to her spectacular discovery of a new family of human retroviruses, and her latest research which points to a new golden age of health, Dr. Mikovits has always been on the leading edge of science.
With the brilliant wit one might expect if Erin Brockovich had a doctorate in molecular biology, Dr. Mikovits has seen the best and worst of science. When she was part of the research community that turned HIV-AIDS from a fatal disease into a manageable one, she saw science at its best. But when her investigations questioned whether the use of animal tissue in medical research were unleashing devastating plagues of chronic diseases, such as autism and chronic fatigue syndrome, she saw science at its worst. If her suspicions are correct, we are looking at a complete realignment of scientific practices, including how we study and treat human disease.
Recounting her nearly four decades in science, including her collaboration of more than thirty-five years with Dr. Frank Ruscetti, one of the founders of the field of human retrovirology, this is a behind the scenes look at the issues and egos which will determine the future health of humanity.
bioRxiv: “Frequent loss-of-heterozygosity in CRISPR-Cas9-edited early human embryos,”
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable editing of the human germline. However, studies assessing gene correction in early human embryos report low efficiency of mutation repair, high rates of mosaicism and the possibility of unintended editing outcomes that may have pathologic consequences. We developed computational pipelines to assess single-cell genomics and transcriptomics datasets from OCT4 (POU5F1) CRISPR-Cas9-targeted and Cas9-only control human preimplantation embryos. This allowed us to evaluate on-target mutations that would be missed by more conventional genotyping techniques. We observed loss-of-heterozygosity in edited cells that spanned regions beyond the POU5F1 on-target locus, as well as segmental loss and gain of chromosome 6, on which the POU5F1 gene is located. Unintended genome editing outcomes were present in approximately 22% of the human embryo cells analysed and spanned 4 to 20kb. Our observations are consistent with recent findings indicating complexity at on-target sites following CRISPR-Cas9 genome editing. Our work underscores the importance of further basic research to assess the safety of genome editing techniques in human embryos, which will inform debates about the potential clinical use of this technology.
team of scientists has used the gene-editing technique CRISPR to create genetically modified human embryos in a London lab, and the results of the experiment do not bode well for the prospect of gene-edited babies.
Biologist Kathy Niakan and her team at the Francis Crick Institute wanted to better understand the role of a particular gene in the earliest stages of human development. So, using CRISPR, they deleted that gene in human embryos that had been donated for research. When they analyzed the edited embryos and compared them to ones that hadn’t been edited, they found something troubling: Around half of the edited embryos contained major unintended edits.
“There’s no sugarcoating this,” says Fyodor Urnov, a gene-editing expert and professor of molecular and cell biology at the University of California, Berkeley. “This is a restraining order for all genome editors to stay the living daylights away from embryo editing.”
According to a troubling scoop by OneZero, a team of London-based scientists used the popular gene-editing technique CRISPR to genetically modify human embryos — with deeply alarming results.
The embryos, none of which were grown past 14 days of maturation, showed a variety of unintended edits to their genes that researchers say could lead to birth defects or even cancer later on in life.
“There’s no sugarcoating this,” Fyodor Urnov, professor of molecular and cell biology at the University of California, Berkeley, who was not involved in the research, told OneZero. “This is a restraining order for all genome editors to stay the living daylights away from embryo editing.”
The team carried out an experiment involving 25 human embryos, seven of which stayed unedited as a control group, as described in a yet-to-be-peer-reviewed preprint paper uploaded to bioRxiv earlier this month. The scientists attempted to edit out the POU5F1 gene, a protein involved in the self-renewal of embryonic stem cells.
But their results suggest that used on human genetic code, CRISPR is more of a butcher’s knife than molecular scissors it’s often compared to: “Unintended genome editing outcomes were present in approximately 22% of the human embryo cells analysed,” reads the paper.
“Our work underscores the importance of further basic research to assess the safety of genome editing techniques in human embryos, which will inform debates about the potential clinical use of this technology,” the researchers concluded.
JRE Clips: Bret Weinstein: Why COVID-19 May Have Leaked from a Lab.
